| 货号: 12263 |
| 产品全名: 人 FGFR2 蛋白 |
| 规格: 10/50/100 µg |
| 基因符号 BEK;JWS;BBDS;CEK3;CFD1;ECT1;KGFR;TK14;TK25;BFR-1;CD332;K-SAM |
| 目标蛋白: FGFR2 |
| UNIPROT ID: P21802 |
| 描述: Recombinant human FGFR2 Protein with C-terminal 6xHis tag |
| 背景: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] |
| 物种/宿主: HEK293 |
| 分子量: The protein has a predicted molecular mass of 39.9 kDa after removal of the signal peptide. The apparent molecular mass of FGFR2-His is approximately 55-100 kDa due to glycosylation. |
| 分子特征: FGFR2(Arg22-Asp374) 6×His tag |
| 纯化: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| 储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Human FGFR2 Protein, His Tag on SDS-PAGE under reducing condition. |
