| 货号: 28251 |
| 产品全名: SIGLEC7(DMC475) IgG1 Chimeric 单抗 |
| 基因符号 AIRM-1; AIRM1; CD328; CDw328; D-siglec; p75; p75:AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2 |
| 描述: SIGLEC7 antibody(DMC475) IgG1 Chimeric 单抗 |
| 背景: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside; disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response; may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34 cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).[UniProtKB:Swiss-Prot Function] |
| 经过测试的应用: Flow Cyt |
| 推荐稀释比: Flow Cyt 1:100 |
| 种属反应性: Rabbit |
| 亚型: Rabbit:Human Fc chimeric IgG1 |
| 纯化: Purified from cell culture supernatant by affinity chromatography |
| 种属反应性: 人 SIGLEC7 |
| 成分: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. |
| 储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). |
Figure 1. Flow cytometry analysis with Anti-SIGLEC7 (DMC475) on Expi293 cells transfected with human SIGLEC7 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram). |
