关于 NewEast Biosciences
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
$659.00
Cat.#: 11810 |
Product Name: SARS-CoV-2 (Omicron BA.5) S Protein RBD |
规格: 10 µg, 50 µg and 100 µg |
Synonyms: SARS-CoV-2 BA.5 (Omicron) Spike RBD Protein |
Target: S protein RBD |
UNIPROT ID: P0DTC2 |
描述: Recombinant SARS-CoV-2 (Omicron BA.5) S-RBD protein with C-terminal human Fc tag |
背景: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as Covid19 (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. The spike protein is a type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which accounts for recognizing the cell surface receptor, ACE2. S2 contains basic elements needed for the membrane fusion. Recent publications indicate that S1-RBD domain can induce virus neutralizing-antibody and T cell response. |
Species/Host: HEK293 |
Molecular Weight: The protein has a predicted molecular mass of 51.4 kDa after removal of the signal peptide. The apparent molecular mass of S-RBD(Omicron BA.5)-hFc is approximately 55-70 kDa due to glycosylation. |
Molecular Characterization: S protein RBD(G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N,N440K, L452R,S477N, T478K, E484A,F486V, Q498R, N501Y, Y505H)(Arg319-Phe541) hFc(Glu99-Ala330) |
纯化: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
![]() Figure 1. SARS-CoV-2 (Omicron BA.5) S protein RBD, hFc Tag on SDS-PAGE under reducing condition. |