武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
¥2,800.00
产品名称: RhoA 小鼠单抗 |
货号: 26007 |
基因符号: RHOA |
描述: RhoA 小鼠单抗 |
背景: Small GTPases are a super-family of cellular signaling regulators. RhoA belongs to the Rho sub-family of GTPases. Rho proteins play critical roles in many actin cytoskeleton- dependent processes including platelet aggregation, cell motility, contraction, and cytokinesis. It regulates the formation of stress fibers and focal adhesions in fibroblasts and Ca2+ sensitivity of smooth muscle contraction. |
免疫原: : Recombinant full length protein of RhoA. |
经过测试的应用: ELISA, WB, IHC |
推荐稀释比: ELISA 1:1000-1:5000 WB 1:1000-1:2000 |
Concentration: 1 mg/ml |
种属反应性: Mouse |
形式: Liquid |
克隆性: Monoclonal |
亚型: IgG |
纯化: Purified from ascites |
成分: : PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
种属反应性: RhoA antibody recognizes RhoA from vertebrates. |
储存条件: Store at -20°C. Avoid repeated freezing and thawing |
1. Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds Commun Biol. 2021 PMID: 34145387 |
2. Acute compressive stress activates RHO/ROCK-mediated cellular processes Small GTPases 2020 PMID: 29455593 |
3. Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells FASEB J. 2018 PMID: 29447006 |
4. Social Isolation Induces Rac1-Dependent Forgetting of Social Memory Cell Rep. 2018 PMID: 30304669 |
5. The Heterotaxy Gene CCDC11 is Essential for Cytokinesis and Cell-Cell Adhesion via RhoA Regulation bioRxiv. 2018 PMID: |
6. Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers Gastroenterology. 2017 PMID: 28522256 |