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JAM-A (DMC278) IgG1 Chimeric mAb

Anti-JAM-A (DMC278) IgG1 Chimeric Monoclonal Antibody
5/5

¥445.00

货号:28186

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   28186
产品全名:   JAM-A(DMC278) IgG1 Chimeric 单抗
基因符号   CD321; JAM;JAM1; JAMA; JCAM; KAT; PAM-1
描述:   JAM-A antibody(DMC278) IgG1 Chimeric 单抗
背景:   Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets; forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition; the encoded protein can act as (1) a receptor for reovirus; (2) a ligand for the integrin LFA1; involved in leukocyte transmigration; and (3) a platelet receptor. Multiple 5' alternatively spliced variants; encoding the same protein; have been identified but their biological validity has not been established.
经过测试的应用:   Flow Cyt
推荐稀释比:   Flow Cyt 1:100
种属反应性:   Rabbit
亚型:   Rabbit:Human Fc chimeric IgG1
纯化:   Purified from cell culture supernatant by affinity chromatography
种属反应性:   人 JAM-A
成分:   Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. JAM-A protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-JAM-A (DMC278) on Expi293 cells transfected with human JAM-A (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and  Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).
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