武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
¥445.00
货号: 28190 |
产品全名: IL11RA(DMC282) IgG1 Chimeric 单抗 |
基因符号 IL-11 R alpha;IL-11 RA;IL11RA;Interleukin-11 receptor subunit alpha;IL-11 receptor subunit alpha;IL-11R subunit alpha;IL-11R-alpha |
描述: IL11RA antibody(DMC282) IgG1 Chimeric 单抗 |
背景: Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor; which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor; since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. |
经过测试的应用: Flow Cyt |
推荐稀释比: Flow Cyt 1:100 |
种属反应性: Rabbit |
亚型: Rabbit:Human Fc chimeric IgG1 |
纯化: Purified from cell culture supernatant by affinity chromatography |
种属反应性: 人 IL11RA |
成分: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. |
储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). |
Figure 1. IL11RA protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-IL11RA (DMC282) on Expi293 cells transfected with human IL11RA (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram). |