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Human MRP1 Protein, hFc Tag

Recombinant human MRP1 protein with C-terminal human Fc tag
5/5

¥415.00

货号:11705

规格: 100 μg

库存状态:Under development

           产品描述          
货号:   11705
产品全名:   人 MRP1 蛋白
规格:   10/50/100 µg
基因符号   HDMX;MDMX;MRP1
目标蛋白:    MRP1
UNIPROT ID:    P33527
描述:   Recombinant human MRP1 protein with C-terminal human Fc tag
背景:     This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
物种/宿主:    HEK293
分子量:   The protein has a predicted molecular mass of 56.7 kDa after removal of the signal peptide.
分子特征:   MRP1(Met1-Phe33) hFc(Glu99-Ala330)
纯化:   The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:   Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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