| 货号: 11648 |
| 产品全名: 人 ITGB7 蛋白 |
| 规格: 10/50/100 µg |
| 基因符号 integrin;beta 7;integrin beta 7 subunit |
| 目标蛋白: ITGB7 |
| UNIPROT ID: P26010 |
| 描述: Recombinant human ITGB7 protein with C-terminal human Fc tag |
| 背景: This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. |
| 物种/宿主: HEK293 |
| 分子量: The protein has a predicted molecular mass of 105.16 kDa after removal of the signal peptide. |
| 分子特征: ITGB7 (Glu20-His723) hFc (Glu99-Ala330) co-translates with ITGAE (Phe19-Ser1124) hFc (Glu99-Ala330). |
| 纯化: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| 储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
