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Human GLP1R Protein, hFc Tag

Recombinant Human GLP1R Protein with C-terminal human Fc tag
5/5

¥389.00

货号:11926

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   11926
产品全名:   人 GLP1R 蛋白
规格:   10/50/100 µg
基因符号   GLP-1;GLP-1-R;GLP-1R
目标蛋白:    GLP1R
UNIPROT ID:    P43220
描述:   Recombinant Human GLP1R Protein with C-terminal human Fc tag
背景:     This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
物种/宿主:    HEK293
分子量:   The protein has a predicted molecular mass of 39.7 kDa after removal of the signal peptide. The apparent molecular mass of GLP1R-hFc is approximately 35-70 kDa due to glycosylation.
分子特征:   GLP1R(Arg24-Glu139) hFc(Glu99-Ala330)
纯化:   The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:   Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human GLP1R Protein, hFc Tag on SDS-PAGE under reducing condition.
           引用文献