| 货号: 11332 |
| 产品全名: 人 AXL 蛋白 |
| 规格: 10/50/100 µg |
| 基因符号 AXL;FO |
| 目标蛋白: AXL |
| UNIPROT ID: P30530 |
| 描述: Recombinant Human AXL with C-terminal human Fc tag |
| 背景: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. |
| 物种/宿主: HEK293 |
| 分子量: The protein has a predicted molecular mass of 71.9 kDa after removal of the signal peptide.The apparent molecular mass of AXL-hFc is approximately 100-130 kDa due to glycosylation. |
| 分子特征: AXL(Ala26-Pro449) hFc(Glu99-Ala330) |
| 纯化: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| 储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Human AXL Protein, hFc Tag on SDS-PAGE under reducing condition. | 
Figure 2. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human AXL, hFc tagged protein (11332) can bind Anti-AXL Neutralizing Antibody 28042 in a linear range of 0.64-80.0 ng/ml. |
|
