武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
¥4,800.00
产品名称: Gαq(Q209L) 小鼠单抗 |
货号: 26328 |
基因符号: GNAQ, CMC1, G-ALPHA-q, GAQ, SWS |
描述: GNAQ(Q209L) 小鼠单抗 |
背景: GNAQ is a protein that in humans encoded by the GNAQ gene. The GNAQ protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospholipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. |
免疫原 : A synthetic peptide from the internal region of GNAQ which includes the mutation of Q209L, human origin. |
经过测试的应用: ELISA, IF, IHC |
推荐稀释比: ELISA: 1:1000-1:2000 WB: 1:500-1:1000 IHC: 1:50-1:100 |
Concentration: 1 mg/ml |
种属反应性: Mouse |
形式: Liquid |
克隆性: Monoclonal |
亚型: IgG |
纯化: Purified from ascites |
成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
种属反应性: Recognizes Gαq(Q209L) mutant, but not wild type Gαq of vertebrates. |
储存条件: Store at -20°C. Avoid repeated freezing and thawing |
Immunofluorescence: Western blot analysis of recombinant GNAQ(Q209L) and wild type proteins. Purified His-tagged GNAQ(Q209L) protein (lane 2) and corresponding wild type protein (lane 1) were blotted with anti-GNAQ(Q209L) monoclonal antibody (货号: 26328). |
Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQQ209L-driven melanoma Oncogenesis. 2016 PMID: 27348266 |