武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
¥2,600.00
产品名称: Gaq 兔多抗 |
货号: 21014 |
基因符号: Gnaq |
描述: Gaq 兔多抗 |
背景: Heterotrimeric G proteins are essential cellular signal transducers. Gaq is a member of the Gq subfamily of G proteins. Gaq is known to stimulate phospholipase C. Other biochemical and physiological functions of Gaq are being explored. |
免疫原: Recombinant full length Gaq 蛋白 |
经过测试的应用: ELISA, WB, IHC |
推荐稀释比: ELISA 1:1000-1:5000WB 1:100-1:2000 |
Concentration: 1 mg/ml |
种属反应性: Rabbit |
形式: Liquid |
克隆性: Polyclonal |
亚型: IgG |
纯化: Purified from serum |
成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
种属反应性: Gaq 兔多抗 recognizes Gaq of vertebrates. |
储存条件: Store at -20°C. Avoid repeated freezing and thawing |
蛋白质印迹: Western blot analysis of Gaq proteins.MEF whole-cell lysates were used for western blot with Anti-Gaq 兔多抗 (cat # 21014). |
1. A G protein-coupled a7 nicotinic receptor regulates signaling and TNF-a release in microglia FEBS Open Bio. 2017 PMID: 28904864 |
2. Alpha 7 nicotinic receptor coupling to heterotrimeric G proteins modulates RhoA activation, cytoskeletal motility, and structural growth J Neurochem. 2016 PMID: 27167578 |
3. Identification and Characterization of a G Protein-binding Cluster in α7 Nicotinic Acetylcholine Receptors J Biol Chem. 2015 PMID: 26088141 |
4. Muscarinic acetylcholine receptor-mediated activation of G(q) in rat brain membranes determined by guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding using an anti-G protein scintillation proximity assay J Neural Transm. 2012 PMID: 22127550 |