武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
¥2,800.00
产品名称: Gα13 小鼠单抗 |
货号: 26004 |
基因符号: Gna13 |
描述: Gα13 小鼠单抗 |
背景: Heterotrimeric G proteins are essential cellular signal transducers. Gα13 is one of the G proteins that could mediate cell migration and angiogenesis. Other biochemical and physiological functions of Gα13 are being explored. |
免疫原 : Recombinant full length Gα13 蛋白 |
经过测试的应用: ELISA, WB, IHC |
推荐稀释比: ELISA 1:1000-1:5000, WB 1:1000-1:2000 |
Concentration: 1 mg/ml |
种属反应性: Mouse |
形式: Liquid |
克隆性: Monoclonal |
亚型: IgG |
纯化: Purified from ascites |
成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
种属反应性: Gα13 monoclonal antibody recognizes Gα13 of vertebrates. |
储存条件: Store at -20°C. Avoid repeated freezing and thawing |
蛋白质印迹: Gα13, Gα12 or Gαqplasmid DNAs were transiently transfected into CHO cells (endogenous Gα13 protein was down-regulated by Gα13siRNA). Whole-cell lysates were used for western blots. |
1. PLEXIN-B2 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the RhoA signaling pathway Cell Signal. 2019 PMID: 31176746 |
2. The interaction of Ga13 with integrin ß1 mediates cell migration by dynamic regulation of RhoA Mol Biol Cell. 2015 PMID: 26310447 |
3. B-lymphocyte Specific loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency J Immunol. 2015 PMID: 26232433 |
4. Evidence of a common mechanism of disassembly of adherens junctions through Ga13 targeting of VE-cadherin J Exp Med. 2014 PMID: 24590762 |
5. A directional switch of integrin signaling and a new anti-thrombotic strategy Nature. 2013 PMID: 24162846 |
6. Suppression of Tumor Angiogenesis by Ga13 Haploinsufficiency J Biol Chem. 2009 PMID: 19654325 |