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Human CCR2 Full Length Protein

Human CCR2 Full Length Protein-Synthetic Nanodisc
5/5

$4,400.00

Cat.#:  11011

   Size:   50 μg

In Stock

          Product Description          
Cat.#:     11011
Product Name:   Human CCR2 Full Length Protein
规格:    10 µg, 50 µg and 100 µg
Synonyms:   CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
Target:    CCR2
UNIPROT ID:    P41597
描述:    Human CCR2 full length protein-synthetic nanodisc
背景:     The protein is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.
Species/Host:    HEK293
Molecular Weight:    The human full length CCR2 protein has a MW of 41.9 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure1. Elisa plates were pre-coated with Flag Tag CCR2-Nanodisc (0.2 µg/per well). Serial diluted Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for Flag monoclonal antibody binding with CCR2-Nanodisc is 7.62ng/ml.

Figure2. Human CCR2-Nanodisc, Flag Tag on SDS-PAGE

Figure3. WB analysis of Human CCR2-Nanodisc with CCR2 monoclonal antibody (28090), followed by Goat Human IgG HRP at 1/5000 dilution
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