武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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TXNIP Rabbit pAb

Anti-TXNIP Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S221070

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S221070
产品全名:   TXNIP 兔多抗
基因符号   THIF; VDUP1; HHCPA78; EST01027
UNIPROT ID:   Q9H3M7 (Gene Accession – NP_006463 )
背景:   May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
抗原:   Synthetic peptide of human TXNIP
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 30-150; ELISA: 2000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Metabolism, Epigenetics and Nuclear Signaling, Cancer, Cell Biology
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 221070(TXNIP Antibody) at a dilution of 1/40(Cytoplasm and Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 221070(Anti-TXNIP Antibody) at dilution 1/40.
           引用文献