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SMAD7 Rabbit pAb

Anti-SMAD7 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S219995

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S219995
产品全名:   SMAD7 兔多抗
基因符号   CRCS3; MADH7; MADH8
UNIPROT ID:   O15105 (Gene Accession – NP_001177750 )
背景:   The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
抗原:   Synthetic peptide of human SMAD7
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-100; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction, Epigenetics and Nuclear Signaling
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 219995(SMAD7 Antibody) at a dilution of 1/50(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the synthetic peptide and then with 219995(Anti-SMAD7 Antibody) at dilution 1/50.
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