武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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ROCK1 Rabbit pAb

Anti-ROCK1 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S216765

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S216765
产品全名:   ROCK1 兔多抗
基因符号   ROCK-I; P160ROCK
UNIPROT ID:   Q13464 (Gene Accession – BC113114 )
背景:   This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
抗原:   Fusion protein of human ROCK1
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 25-100; ELISA: 2000-5000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction, Cancer
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 216765(ROCK1 Antibody) at a dilution of 1/25(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the fusion protein and then with 216765(Anti-ROCK1 Antibody) at dilution 1/25.
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