武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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PPARD Rabbit pAb

Anti-PPARD Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S213940

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S213940
产品全名:   PPARD 兔多抗
基因符号   FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
UNIPROT ID:   Q03181 (Gene Accession – NP_803184 )
背景:   This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
抗原:   Synthetic peptide of human PPARD
经过测试的应用:   ELISA, WB, IHC
推荐稀释比:   IHC: 50-300;WB: 200-1000;ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling, Metabolism, Cardiovascular
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 213940(PPARD Antibody) at a dilution of 1/55(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the synthetic peptide and then with 213940(Anti-PPARD Antibody) at dilution 1/55.

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 213940(Anti-PPARD Antibody) at a dilution of 1/55.

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with synthetic peptide and then with D161088(Anti-PPARD Antibody) at dilution 1/55.

Gel: 8%SDS-PAGE, Lysate: 40 μg;
Lane: HEPG2 cell lysate;
Primary antibody: 213940(PPARD Antibody) at dilution 1/200;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 40 seconds
           引用文献