武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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PIM1 Rabbit mAb

Anti-PIM1 Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N263122

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N263122
产品全名:   PIM1 兔单克隆抗体
基因符号   PIM1; Serine/threonine-protein kinase pim-1
UNIPROT ID:   P11309
背景:   Pim1 a proto-oncogene serine/threonine kinase involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.
抗原:   A synthetic peptide of human PIM1
经过测试的应用:   WB,IHC-P
推荐稀释比:   WB: 1/500-1/1000 IHC: 1/50-1/100
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R08-8D5
分子量:   Calculated MW: 36 kDa; Observed MW: 36 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human tonsil using PIM1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of PIM1 in Hela, A549, HL-60 lysates using PIM1 antibody.
           引用文献