Cat.#: S220315 |
Product Name: Anti-PIK3C3 Rabbit Polyclonal Antibody |
Synonyms: VPS34; hVps34 |
UNIPROT ID: Q8NEB9 (Gene Accession – NP_002638 ) |
Background: Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme that in humans is encoded by thePIK3C3 gene. PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. |
Immunogen: Synthetic peptide of human PIK3C3 |
Applications: ELISA, IHC |
Recommended Dilutions: IHC: 50-200; ELISA: 1000-5000 |
Host Species: Rabbit |
Clonality: Rabbit Polyclonal |
Isotype: Immunogen-specific rabbit IgG |
Purification: Antigen affinity purification |
Species Reactivity: Human, Mouse, Rat |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
Research Areas: Signal Transduction, Metabolism, Immunology |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 220315(PIK3C3 Antibody) at a dilution of 1/40(Cytoplasm). | In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 220315(Anti-PIK3C3 Antibody) at dilution 1/40. | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 220315(Anti-PIK3C3 Antibody) at a dilution of 1/40. | In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D261326(Anti-PIK3C3 Antibody) at dilution 1/40. |
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