| 货号: S219654 |
| 产品全名: NPR1 兔多抗 |
| 基因符号 ANPa, NPRA, ANPRA, GUC2A, GUCY3A |
| UNIPROT ID: P16066 (Gene Accession – NP_000897 ) |
| 背景: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms . The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively). |
| 抗原: Synthetic peptide of human NPR1 |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 25-100; ELISA: 1000-5000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse, Rat |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Signal Transduction, Cardiovascular |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human brain tissue using 219654(NPR1 Antibody) at a dilution of 1/30(Cytoplasm, Nucleus, Cell membrane). | 
In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 219654(Anti-NPR1 Antibody) at dilution 1/30. | 
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 219654(Anti-NPR1 Antibody) at a dilution of 1/30. | 
In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D260091(Anti-NPR1 Antibody) at dilution 1/30. |
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