货号: N261447 |
产品全名: Lamin A/C (5D12) 小鼠单抗 |
基因符号 LMNA; LMN1; Prelamin-A/C |
UNIPROT ID: P02545 |
背景: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. |
抗原: Purified recombinant human LMNA protein fragments expressed in E.coli. |
经过测试的应用: WB,ICC/IF |
推荐稀释比: WB: 1/500-1/1000 IF: 1/50-1/200 |
种属反应性: Mouse |
克隆性: Mouse Monoclonal |
克隆编号: 5D12-C6-E9 |
分子量: Calculated MW: 74 kDa; Observed MW: 63,74 kDa |
亚型: IgG1 |
纯化: Affinity Purified |
种属反应性: Human, Mouse and Rat |
成分: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
研究领域: Tags & Cell Markers |
储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunofluorescence analysis of Lamin A/C (5D12) in A549 using Lamin A/C antibody. | Western blot analysis of Lamin A/C in MCF-7, A549 and Hela lysates using Lamin A/C antibody. |
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