武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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KDM4D Rabbit pAb

Anti-KDM4D Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S211306

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S211306
产品全名:   KDM4D 兔多抗
基因符号   JMJD2D
UNIPROT ID:   Q6B0I6 (Gene Accession – BC122858 )
背景:   JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.
抗原:   Fusion protein of human KDM4D
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 25-100; ELISA: 1000-2000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human prostate cancer tissue using 211306(KDM4D Antibody) at a dilution of 1/60(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with the fusion protein and then with 211306(Anti-KDM4D Antibody) at dilution 1/60.
           引用文献