| 货号: N261122 |
| 产品全名: JNK1 (1A4) 小鼠单抗 |
| 基因符号 AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08_HUMAN; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase; mitogen-activated; 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1 . |
| UNIPROT ID: P45983 |
| 背景: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016] |
| 抗原: Purified recombinant human JNK1 protein fragments expressed in E.coli. |
| 经过测试的应用: WB,ICC/IF |
| 推荐稀释比: WB: 1/500-1/1000 IF: 1/50-1/200 |
| 种属反应性: Mouse |
| 克隆性： Mouse Monoclonal |
| 克隆编号: 1A4-C5-F11 |
| 分子量: Calculated MW: 48 kDa; Observed MW: 46,54 kDa |
| 亚型: IgG2a |
| 纯化: Affinity Purified |
| 种属反应性: Human, Mouse and Rat |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| 研究领域: Signal Transduction |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunofluorescence analysis of JNK1 (1A4) in 3T3 using JNK1 antibody. | 
Western blot analysis of JNK1 in C6 and 3T3 lysates using JNK1 antibody. | 
Western blot analysis of JNK1 (1A4) in CHO-K1 cell lysates(B) and CHO-K1 transfected by JNK1fragment fusion protein(A) cell lysates using JNK1 antibody. | |
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