| 货号: N261764 |
| 产品全名: CDK5RAP3 兔单克隆抗体 |
| 基因符号 C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114 |
| UNIPROT ID: Q96JB5 |
| 背景: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). |
| 抗原: A synthetic peptide of human CDK5RAP3 |
| 经过测试的应用: WB,IHC-P,IP |
| 推荐稀释比: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Monoclonal |
| 克隆编号: R07-1A1 |
| 分子量: Calculated MW: 57 kDa; Observed MW: 70 kDa |
| 亚型: IgG |
| 纯化: Affinity Purified |
| 种属反应性: Human,Mouse |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| 研究领域: Cell Biology |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using CDK5RAP3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. | 
Western blot analysis of CDK5RAP3 in K562, Hela lysates using CDK5RAP3 antibody. |
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