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Phospho-CBL (Tyr774) Rabbit mAb

Anti-Phospho-CBL (Tyr774) Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N261727

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N261727
产品全名:   Phospho-CBL (Tyr774) 兔单克隆抗体
基因符号   CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL
UNIPROT ID:   P22681
背景:   This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder
抗原:   A synthetic phosphopeptide corresponding to residues surrounding Tyr774 of human CBL
经过测试的应用:   WB,IP
推荐稀释比:   WB: 1/500-1/1000 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R07-8A3
分子量:   Calculated MW: 100 kDa; Observed MW: 120 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human,Rat
Modification:   Phosphorylated
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Cell Biology
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Phospho-CBL (Tyr774) in K562, C6, Hela lysates using Phospho-CBL (Tyr774) antibody.
           引用文献