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KIF7 (2A7) Mouse mAb

Anti-KIF7 (2A7) Mouse Monoclonal Antibody
5/5

¥2,850.00

货号:N261223

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N261223
产品全名:   KIF7 (2A7) 小鼠单抗
基因符号   kinesin like protein KIF7; EQYK340; kif7
UNIPROT ID:   Q2M1P5
背景:   Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation . Involved in the regulation of epidermal differentiation and chondrocyte development .
抗原:   Synthetic Peptide of Kif 7
经过测试的应用:   IHC-P,ICC/IF
推荐稀释比:   IHC: 1/50-1/100 IF: 1/50-1/200
种属反应性:   Mouse
克隆性:   Mouse Monoclonal
克隆编号:   2A7-10B8-9A9
分子量:   
亚型:   IgG1
纯化:   Affinity Purified
种属反应性:   Human, Mouse and Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded mouse Kidney tissue using KIF7 (2A7) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescence analysis of KIF7 (2A7) in mouse colon using KIF7 (2A7) antibody(red),and DAPI (blue).
           引用文献