| 货号: S221581 |
| 产品全名: ERBB4 兔多抗 |
| 基因符号 HER4; ALS19; p180erbB4 |
| UNIPROT ID: Q15303 (Gene Accession – NP_005226 ) |
| 背景: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| 抗原: Synthetic peptide of human ERBB4 |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 20-100; ELISA: 5000-10000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse, Rat |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Signal Transduction, Cancer |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human ovarian cancer tissue using 221581(ERBB4 Antibody) at a dilution of 1/25(Nucleus or Cell membrane). | 
In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with the synthetic peptide and then with 221581(Anti-ERBB4 Antibody) at dilution 1/25. | 
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using 221581(Anti-ERBB4 Antibody) at a dilution of 1/25. | 
In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with synthetic peptide and then with D263229(Anti-ERBB4 Antibody) at dilution 1/25. |
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