| 货号: S220458 |
| 产品全名: CHRDL2 兔多抗 |
| 基因符号 BNF1; CHL2; FKSG37 |
| UNIPROT ID: Q6WN34 (Gene Accession – NP_056239 ) |
| 背景: CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis. |
| 抗原: Synthetic peptide of human CHRDL2 |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 25-100; ELISA: 2000-5000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Signal Transduction, Cardiovascular |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 220458(CHRDL2 Antibody) at a dilution of 1/20(Cytoplasm). | 
In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 220458(Anti-CHRDL2 Antibody) at dilution 1/20. | 
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 220458(Anti-CHRDL2 Antibody) at a dilution of 1/20. | 
In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with synthetic peptide and then with D261558(Anti-CHRDL2 Antibody) at dilution 1/20. |
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