武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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HIPK3 Rabbit pAb

Anti-HIPK3 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S220329

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S220329
产品全名:   HIPK3 兔多抗
基因符号   PKY; YAK1; DYRK6; FIST3
UNIPROT ID:   Q9H422 (Gene Accession – NP_001041665 )
背景:   Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
抗原:   Synthetic peptide of human HIPK3
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-300; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction, Epigenetics and Nuclear Signaling, Cancer
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colorectal cancer tissue using 220329(HIPK3 Antibody) at a dilution of 1/60(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with the synthetic peptide and then with 220329(Anti-HIPK3 Antibody) at dilution 1/60.
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