| 货号: S219811 |
| 产品全名: CLDN7 兔多抗 |
| 基因符号 CLDN-7, CEPTRL2, CPETRL2, Hs.84359, claudin-1 |
| UNIPROT ID: O95471 (Gene Accession – NP_001298 ) |
| 背景: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found. |
| 抗原: Synthetic peptide of human CLDN7 |
| 经过测试的应用: ELISA, WB, IHC |
| 推荐稀释比: IHC: 50-150;WB: 1000-3000;ELISA: 1000-10000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse, Rat |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Signal Transduction |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 219811(CLDN7 Antibody) at a dilution of 1/50(Cytoplasm, Cell membrane). | 
In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 219811(Anti-CLDN7 Antibody) at dilution 1/50. | 
The image on the left is immunohistochemistry of paraffin-embedded Human stomach cancer tissue using 219811(Anti-CLDN7 Antibody) at a dilution of 1/50. | 
In comparision with the IHC on the left, the same paraffin-embedded Human stomach cancer tissue is first treated with synthetic peptide and then with D260406(Anti-CLDN7 Antibody) at dilution 1/50. | 
Gel: 10%SDS-PAGE, Lysate: 30 μg;
Lane: Human liver cancer tissue;
Primary antibody: 219811(CLDN7 Antibody) at dilution 1/1050;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 40 seconds | |
|
