| 货号: S219700 |
| 产品全名: KRT6A/KRT6B/KRT6C 兔多抗 |
| 基因符号 K6A; K6C; K6D; CK6A; CK6C; CK6D; KRT6C; KRT6D; K6B; PC2; CK6B; CK-6B; KRTL1; K6E; KRT6E |
| UNIPROT ID: P02538/P04259/P48668 (Gene Accession – NP_005545.1/NP_005546.2/NP_775109.2 ) |
| 背景: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
| 抗原: Synthetic peptide of human KRT6A/KRT6B/KRT6C |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 50-200; ELISA: 2000-5000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Signal Transduction, Immunology |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 219700(KRT6A/KRT6B/KRT6C Antibody) at a dilution of 1/50(Cytoplasm). | 
In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 219700(Anti-KRT6A/KRT6B/KRT6C Antibody) at dilution 1/50. | 
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 219700(Anti-KRT6A/KRT6B/KRT6C Antibody) at a dilution of 1/50. | 
In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D260177(Anti-KRT6A/KRT6B/KRT6C Antibody) at dilution 1/50. |
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