武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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DNMT3L Rabbit pAb

Anti-DNMT3L Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S216475

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S216475
产品全名:   DNMT3L 兔多抗
基因符号   
UNIPROT ID:   Q9UJW3 (Gene Accession – BC002560 )
背景:   CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
抗原:   Fusion protein of human DNMT3L
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: Oct-50; ELISA: 1000-2000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 216475(DNMT3L Antibody) at a dilution of 1/15(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 216475(Anti-DNMT3L Antibody) at dilution 1/15.
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