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PD-L1 (DM124) Rabbit mAb

Anti-PD-L1 (DM124) Rabbit Monoclonal Antibody
5/5

¥445.00

货号:28469

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   28469
产品全名:   PD-L1(DM124) 兔单克隆抗体
基因符号   PD-L1; CD274; B7-H1; PDCD1L1; PDCD1LG1
描述:   PD-L1 antibody(DM124) 兔单克隆抗体
背景:   This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells; such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue; this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments; this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies; including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
经过测试的应用:   ELISA; Flow Cyt
推荐稀释比:   ELISA 1:5000-10000; Flow Cyt 1:100
种属反应性:   Rabbit
亚型:   Rabbit IgG
纯化:   Purified from cell culture supernatant by affinity chromatography
种属反应性:   人 PD-L1
成分:   Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human PD-L1 protein, mFc His tagged protein 11151 can bind Rabbit anti-PD-L1 monoclonal antibody  (clone: DM124) in a linear range of 0.1-15 ng/ml.

Figure 2. Flow cytometry analysis with Anti-PD-L1  (DM124) on Expi293 cells transfected with human PD-L1 (Blue histogram) or Expi293 transfected with irrelevant protein(Red histogram).
           引用文献