| 货号: 11605 |
| 产品全名: 人 CCR4 (1-39) 蛋白 |
| 规格: 10/50/100 µg |
| 基因符号 CC-CKR-4;CD194;ChemR13;CKR4;CMKBR4;HGCN:14099;K5-5 |
| 目标蛋白: CCR4 |
| UNIPROT ID: P51679 |
| 描述: Recombinant Human CCR4 with C-terminal human Fc tag |
| 背景: The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine – MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008] |
| 物种/宿主: HEK293 |
| 分子量: The protein has a predicted molecular mass of 30.6 kDa after removal of the signal peptide.The apparent molecular mass of CCR4-hFc is approximately 35-55 kDa due to glycosylation. |
| 分子特征: CCR4(Met1-Glu39) hFc(Glu99-Ala330) |
| 纯化: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| 储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Human CCR4 Protein, hFc Tag on SDS-PAGE under reducing condition. | 
Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human CCR4(1-39) Protein, hFc Tag ( 11605) can bind Anti-CCR4 Neutralizing antibody 28089 in a linear range of 1.02-740.74 ng/mL. |
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