武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
¥2,600.00
产品名称: ErbB2 兔多抗 |
货号: 21202 |
基因符号: ERBB2/HER2/Neu |
描述: ErbB2 兔多抗 |
背景: The ErbB family is composed of four plasma membrane-bound receptor tyrosine kinases. Amplification or over-expression of the ERBB2 gene occurs in approximately 30% of breast cancers. HER2 is encoded by ERBB2, a known proto-oncogene located at the long arm of human chromosome 17(17q21-q22). HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis. |
免疫原 : A synthetic peptide from the central of ErbB2 protein. |
经过测试的应用: ELISA, WB, IHC |
推荐稀释比: ELISA: 1:500-1:5000 WB: 1:200-1:2000 IHC: 1:20-1:200 |
Concentration: 0.2 mg/ml |
种属反应性: Rabbit |
形式: Liquid |
克隆性: Polyclonal |
亚型: IgG |
纯化: Purified from serum |
成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
种属反应性: Recognizes ErbB2 of vertebrates. |
储存条件: Store at -20°C. Avoid repeated freezing and thawing. |
蛋白质印迹: Western blot analysis of ErbB2 protein. Purified full length His-tagged ErbB2 protein (货号:10208) was blotted with Anti-ErbB2 兔多抗 (货号:21202). Immunohistochemical analysis of paraffin-embedded human breast cancer tissue with Anti-ErbB2 兔多抗 (货号:21202). Tissue samples were fixed with formaldehyde and blocked with 1% serum for 15 min at 37 °C. Antigen retrieval was by heat mediation in citrate buffer (pH6). Samples were then incubated with primary antibody (1:50 dilution) overnight at 4 °C. A HRP-conjugated Goat anti-Rabbit IgG (1:50) was used as secondary antibody. |