| 货号: 11330 |
| 产品全名: 人 CD38 蛋白 |
| 规格: 10/50/100 µg |
| 基因符号 CD38, T10, cADPr hydrolase 1 |
| 目标蛋白: CD38 |
| UNIPROT ID: P28907 |
| 描述: Recombinant human CD38 protein with C-terminal human Fc tag |
| 背景: CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia. |
| 物种/宿主: HEK293 |
| 分子量: The protein has a predicted molecular mass of 56.0 kDa after removal of the signal peptide.The apparent molecular mass of CD38-hFc is approximately 70-100 kDa due to glycosylation. |
| 分子特征: CD38(Val43-Ile300) hFc(Glu99-Ala330) |
| 纯化: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| 储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Human CD38, hFc Tag on SDS-PAGE under reducing condition. | 
Figure 2. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human CD38, hFc tagged protein (11132) can bind anti-CD38 antibody, Rabbit mAb clone:DM30 in a linear range of 0.64-80 ng/ml. |
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