武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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BRCA2 Rabbit pAb

Anti-BRCA2 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S219679

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S219679
产品全名:   BRCA2 兔多抗
基因符号   FAD, FACD, FAD1, GLM3, BRCC2, FANCB, FANCD, PNCA2, FANCD1, BROVCA2
UNIPROT ID:   P51587 (Gene Accession – NP_000050 )
背景:   Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
抗原:   Synthetic peptide of human BRCA2
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 25-100; ELISA: 2000-5000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling, Cancer
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 219679(BRCA2 Antibody) at a dilution of 1/35(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the synthetic peptide and then with 219679(Anti-BRCA2 Antibody) at dilution 1/35.
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