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Phospho-Rb2 p130 (Thr986) Rabbit mAb

Anti-Phospho-Rb2 p130 (Thr986) Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N261714

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N261714
产品全名:   Phospho-Rb2 p130 (Thr986) 兔单克隆抗体
基因符号   Rb2; P130
UNIPROT ID:   Q08999
背景:   Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 ‘Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
抗原:   A synthetic phosphopeptide corresponding to residues surrounding Thr986 of human p130
经过测试的应用:   WB,IP
推荐稀释比:   WB: 1/500-1/1000 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R06-9B3
分子量:   Calculated MW: 128 kDa; Observed MW: 128 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human
Modification:   Phosphorylated
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Cell Biology
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Phospho-Rb2 p130 (Thr986) in K562 lysates using Phospho-Rb2 p130 (Thr986) antibody.
           引用文献