武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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UHRF1 Rabbit mAb

Anti-UHRF1 Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N261599

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N261599
产品全名:   UHRF1 兔单克隆抗体
基因符号   Np95; hNP95; ICBP90; RNF106
UNIPROT ID:   Q96T88
背景:   This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
抗原:   Recombinant protein of human UHRF1
经过测试的应用:   WB,IP
推荐稀释比:   WB: 1/500-1/1000 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R06-1C4
分子量:   Calculated MW: 90 kDa; Observed MW: 97 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Epigenetics and Nuclear Signaling
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of UHRF1 in K562, Hela lysates using UHRF1 antibody.
           引用文献