| 货号: S214555 |
| 产品全名: TP53INP1 兔多抗 |
| 基因符号 SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B |
| UNIPROT ID: Q96A56 (Gene Accession – NP_150601 ) |
| 背景: TP53INP1 (tumor protein p53-inducible nuclear protein 1), also known as p53DINP1, SIP or Teap, is a 240 amino acid protein that localizes to nuclear bodies and exists as two alternatively spliced isoforms, designated p53DINP1a and p53DINP1b. Expressed ubiquitously with higher expression in testis, pancreas and spleen tissue, TP53INP1 functions in response to double-stranded DNA breaks and regulates p53-mediated apoptosis, specifically by phosphorylating human p53 at Ser 46, an event that leads to cell death. Additionally, TP53INP1 is thought to interact with p73 and may be involved in the regulation of p73-controlled cell cycle progression. TP53INP1 expression is downregulated in pancreatic ductal adenocarcinomas, suggesting that, via its ability to induce cell death, TP53INP1 plays a role in tumor suppression. |
| 抗原: Synthetic peptide of human TP53INP1 |
| 经过测试的应用: ELISA, WB, IHC |
| 推荐稀释比: IHC: 50-200;WB: 200-1000;ELISA: 1000-2000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Cancer |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human brain tissue using 214555(TP53INP1 Antibody) at a dilution of 1/50(Cytoplasm). | 
In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 214555(Anti-TP53INP1 Antibody) at dilution 1/50. | 
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using 214555(Anti-TP53INP1 Antibody) at a dilution of 1/50. | 
In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with synthetic peptide and then with D162004(Anti-TP53INP1 Antibody) at dilution 1/50. | 
Gel: 10%SDS-PAGE, Lysate: 40 μg;
Lane 1-3: Human fetal liver tissue, 293T cells, 231 cells;
Primary antibody: 214555(TP53INP1 Antibody) at dilution 1/200;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 1 minute | |
|
